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CoFactor: Flavin Mononucleotide

General information

2D representation

Flavin Mononucleotide

Key facts

Cofactor type    coenzyme or prosthetic group
Human metabolism    Vitamin B2
IUPAC name    1-deoxy-1-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)-5-O-phosphono-D-ribitol
Curator    JDF

Tags

Molecular function

Flavin mononucleotide (FMN) is involved in both one and two electron transfer reactions [3] and in radical reactions [1].

Chemical properties

Flavins can build stable semiquinone radicals under anaerobic conditions [1]. Vitamin B2 is the universal precursor of all flavo-cofactors [2].

Pathways

The flavin biosynthetic pathway is found in plants and microorganisms [4]. The flavin-dependent enzyme glycine oxidase is involved in thiamine biosynthesis.

Comment

FMN can be both a prosthetic group and a coenzyme. An example mechanism in which it is an coenzyme is the enzyme alkanal monooxygenase.

References

[1] pubmed:16704345
[2] pubmed:16010344
[3] pubmed:17275397
[4] pubmed:17898895
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