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Search The CSA
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EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 8tln

E.C. namethermolysin
SpeciesBacillus thermoproteolyticus (Bacteria)
E.C. Number (IntEnz) 3.4.24.27
CSA Homologues of 8tlnThere are 81 Homologs
CSA Entries With UniProtID P00800
CSA Entries With EC Number 3.4.24.27
PDBe Entry 8tln
PDBSum Entry 8tln
MACiE Entry M0176

Literature Report

IntroductionThis entry covers the metalloproteinase family M4 ( see [REF: 1] for metalloproteinase classification), which contains thermolysin (EC3.4.24.27), bacillolysins (EC 3.4.24.28), pseudolysins (EC 3.4.24.26), Vibriolysin (EC3.4.24.25) and several other proteases which do not have EC numbers. Family M4 are the only members of clan MA to have structures within the PDB. The active site lies between the two domains and contains a catalytic zinc ion.
Mechansim

Catalytic Sites for 8tln

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
HisE231463macie:sideChain
GluE143375macie:sideChain

Literature References

Notes:
Rawlings ND
Evolutionary families of metallopeptidases.
Methods Enzymol 1995 248 183-228
PubMed: 7674922
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