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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 3cla

E.C. namechloramphenicol O-acetyltransferase
SpeciesEscherichia coli (Bacteria)
E.C. Number (IntEnz) 2.3.1.28
CSA Homologues of 3claThere are 12 Homologs
CSA Entries With UniProtID P00484
CSA Entries With EC Number 2.3.1.28
PDBe Entry 3cla
PDBSum Entry 3cla
MACiE Entry 3cla

Literature Report

Introduction
Mechansim
Reaction

Catalytic Sites for 3cla

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
AspA199193macie:sideChain
HisA195189macie:sideChain
ArgA1813macie:sideChain

Literature References

Notes:
Shaw WV
Chloramphenicol acetyltransferase.
Annu Rev Biophys Biophys Chem 1991 20 363-386
PubMed: 1867721
Leslie AG.
Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution.
J Mol Biol 1990 213 167-186
PubMed: 2187098
Lewendon A
Replacement of catalytic histidine-195 of chloramphenicol acetyltransferase: evidence for a general base role for glutamate.
Biochemistry 1994 33 1944-1950
PubMed: 7906544
Lewendon A
Transition state stabilization by chloramphenicol acetyltransferase. Role of a water molecule bound to threonine 174.
J Biol Chem 1993 268 20997-21001
PubMed: 8407936
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