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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 2ypn

E.C. namehydroxymethylbilane synthase
SpeciesEscherichia coli (Bacteria)
E.C. Number (IntEnz) 2.5.1.61
CSA Homologues of 2ypn1ah5,1gtk,1pda,1ypn,3ecr,
CSA Entries With UniProtID P06983
CSA Entries With EC Number 2.5.1.61
PDBe Entry 2ypn
PDBSum Entry 2ypn
MACiE Entry M0260

Literature Report

Introduction
Mechansim
Reaction

Catalytic Sites for 2ypn

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
CysA242242macie:sideChain
ArgA155155macie:sideChain
AspA8484macie:sideChain
ArgA131131macie:sideChain
ArgA149149macie:sideChain
ArgA132132macie:sideChain

Literature References

Notes:
Woodcock SC
Evidence for participation of aspartate-84 as a catalytic group at the active site of porphobilinogen deaminase obtained by site-directed mutagenesis of the hemC gene from Escherichia coli.
Biochemistry 1994 33 2688-2695
PubMed: 8117733
Shoolingin-Jordan PM
Discovery that the assembly of the dipyrromethane cofactor of porphobilinogen deaminase holoenzyme proceeds initially by the reaction of preuroporphyrinogen with the apoenzyme.
Biochem J 1996 316 ( Pt 2) 373-376
PubMed: 8687374
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