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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 2phk

E.C. namephosphorylase kinase
SpeciesOryctolagus cuniculus (Rabbit)
E.C. Number (IntEnz) 2.7.11.19
CSA Homologues of 2phkThere are 1416 Homologs
CSA Entries With UniProtID P00518
CSA Entries With EC Number 2.7.11.19
PDBe Entry 2phk
PDBSum Entry 2phk
MACiE Entry M0035

Literature Report

Introduction
Mechansim

Catalytic Sites for 2phk

Annotated By Reference To The Literature - Site 2 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
LysA151152macie:sideChainTransition state stabiliser.
AspA149150macie:sideChainActs as a general acid/base catalyst.

Literature References

Notes:
Lowe ED
The crystal structure of a phosphorylase kinase peptide substrate complex: kinase substrate recognition.
EMBO J 1997 16 6646-6658
PubMed: 9362479
Skamnaki VT
Catalytic mechanism of phosphorylase kinase probed by mutational studies.
Biochemistry 1999 38 14718-14730
PubMed: 10545198
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