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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 1ni4

E.C. namepyruvate dehydrogenase (acetyl-transferring)
SpeciesHomo sapiens (Human)
E.C. Number (IntEnz) 1.2.4.1
CSA Homologues of 1ni4There are 98 Homologs
CSA Entries With UniProtID P08559
CSA Entries With EC Number 1.2.4.1
PDBe Entry 1ni4
PDBSum Entry 1ni4
MACiE Entry 1ni4

Literature Report

Introduction
Mechansim
Reaction

Catalytic Sites for 1ni4

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
HisC263292macie:sideChain
GluB5989macie:sideChain
HisB128158macie:sideChain

Annotated By Reference To The Literature - Site 2 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
HisA263292macie:sideChain
GluD5989macie:sideChain
HisD128158macie:sideChain

Literature References

Notes:
Hübner G
Activation of thiamin diphosphate in enzymes.
Biochim Biophys Acta 1998 1385 221-228
PubMed: 9655909
Aevarsson A
Crystal structure of 2-oxoisovalerate and dehydrogenase and the architecture of 2-oxo acid dehydrogenase multienzyme complexes.
Nat Struct Biol 1999 6 785-792
PubMed: 10426958
Ciszak EM
Structural basis for flip-flop action of thiamin pyrophosphate-dependent enzymes revealed by human pyruvate dehydrogenase.
J Biol Chem 2003 278 21240-21246
PubMed: 12651851
Fries M
Reaction mechanism of the heterotetrameric (alpha2beta2) E1 component of 2-oxo acid dehydrogenase multienzyme complexes.
Biochemistry 2003 42 6996-7002
PubMed: 12795594
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