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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 1dzr

E.C. namedTDP-4-dehydrorhamnose 3,5-epimerase
SpeciesSalmonella typhimurium (Bacteria)
E.C. Number (IntEnz) 5.1.3.13
CSA Homologues of 1dzrThere are 21 Homologs
CSA Entries With UniProtID P26394
CSA Entries With EC Number 5.1.3.13
PDBe Entry 1dzr
PDBSum Entry 1dzr
MACiE Entry M0329

Literature Report

IntroductiondTDP-4-dehydrorhamnose 3,5-epimerase is the third enzyme in the biosynthetic pathway of dTDP-L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. The pathway does not exist in humans and therefore the enzymes in it are potential drug targets. The enzyme fold is unlike that of any other known epimerase and so represents a novel class of epimerase.
MechansimMechanism unknown, the reaction is thought to be a novel one.
Reaction

Catalytic Sites for 1dzr

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
AspA170170macie:sideChain
HisA6363macie:sideChain

Annotated By Reference To The Literature - Site 2 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
AspB170170macie:sideChain
HisB6363macie:sideChain

Literature References

Notes:
Giraud MF
RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase.
Nat Struct Biol 2000 7 398-402
PubMed: 10802738
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