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EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 1avf

E.C. namegastricsin
SpeciesHomo sapiens (Human)
E.C. Number (IntEnz)
CSA Homologues of 1avfThere are 301 Homologs
CSA Entries With UniProtID P20142
CSA Entries With EC Number
PDBe Entry 1avf
PDBSum Entry 1avf
MACiE Entry 1avf

Literature Report

IntroductionProgastricsin is a major seminal plasma protein having aspartic protease-like activity and showing close sequence and structure similarity to pepsins. The catalytic site of pepsin-like enzymes is formed at the junction of the two domains of the protein and contains two catalytic aspartic acid residues, one in each domain.
MechansimThe mechanism proceeds via a general acid/base mechanism and involves nucleophilic attack by an activated water molecule on the substrate.

Catalytic Sites for 1avf

Literature References

Hassan MI
Progastriscin: structure, function, and its role in tumor progression.
J Mol Cell Biol 2010 2 118-127
PubMed: 20231168
Karlsen S
Structure and proposed amino-acid sequence of a pepsin from atlantic cod (Gadus morhua).
Acta Crystallogr D Biol Crystallogr 1998 54 32-46
PubMed: 9761815
Andreeva NS
Analysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymes.
Protein Sci 2001 10 2439-2450
PubMed: 11714911
Khan AR
Structural characterization of activation 'intermediate 2' on the pathway to human gastricsin.
Nat Struct Biol 1997 4 1010-1015
PubMed: 9406551