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Catalytic Site Atlas

CSA LITERATURE entry for 1a4g

E.C. nameexo-alpha-sialidase
SpeciesInfluenza b virus (Virus)
E.C. Number (IntEnz) 3.2.1.18
CSA Homologues of 1a4gThere are 92 Homologs
CSA Entries With UniProtID P27907
CSA Entries With EC Number 3.2.1.18
PDBe Entry 1a4g
PDBSum Entry 1a4g
MACiE Entry 1a4g

Literature Report

IntroductionNeuraminidases, also called sialidases, catalyse the hydrolysis of terminal sialic acid residues from newly formed virions and from host cell receptors. These activities are very important for the survival of the influenza virus. Neuraminidases are therefore a key target for antiviral drugs.
Mechansim
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Catalytic Sites for 1a4g

Literature References

Notes:Most articles referring to the catalytic mechanism of neuraminidase base their analysis on the "Phillips mechanism" for lysozyme, which has now been demonstrated to be incorrect. There is therefore no correct published mechanism for Influenza B/Beijing/1987 neuraminidase. It is likely to proceed through a covalent intermediate like lysozyme but this has not been confirmed. For example, the transition state may be stabilised by a tyrosine residue (PMID: 8535779).
Davies G
Structures and mechanisms of glycosyl hydrolases.
Structure 1995 3 853-859
PubMed: 8535779
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