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Search The CSA
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Catalytic Site Atlas

CSA LITERATURE entry for 2acy

E.C. nameacylphosphatase
SpeciesBos taurus (Bovine)
E.C. Number (IntEnz) 3.6.1.7
CSA Homologues of 2acyThere are 21 Homologs
CSA Entries With UniProtID P41500
CSA Entries With EC Number 3.6.1.7
PDBe Entry 2acy
PDBSum Entry 2acy
MACiE Entry 2acy

Literature Report

IntroductionAcylphosphatase is one of the smallest enzymes, with only 98 residues. The exact biological function of ACP (Acylphosphatase) is unknown, but may involve regulation in all metabolic pathways involving acylphosphates, especially glycolysis and pyrimidine biosynthesis. It is found in many vertebrate tissues in two homologous isoforms.
MechansimLittle is known about the mechanism. Asn41 is thought to polarise and orient a water molecule, which is the attacking nucleophile of the leaving phosphate group. Asn41 is essential for catalysis as determined by mutagenesis. Arg23 is thought to stabilise the intermediate.
Reaction

Catalytic Sites for 2acy

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
ArgA2326macie:sideChain
AsnA4144macie:sideChain

Literature References

Notes:
Thunnissen MM
Crystal structure of common type acylphosphatase from bovine testis.
Structure 1997 5 69-79
PubMed: 9016712
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