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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 1sme

E.C. nameplasmepsin II
SpeciesPlasmodium falciparum ()
E.C. Number (IntEnz) 3.4.23.39
CSA Homologues of 1smeThere are 261 Homologs
CSA Entries With UniProtID P46925
CSA Entries With EC Number 3.4.23.39
PDBe Entry 1sme
PDBSum Entry 1sme
MACiE Entry 1sme

Literature Report

Introduction
Mechansim
Reaction

Catalytic Sites for 1sme

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
AspA34158macie:sideChain
AspA214338macie:sideChain
SerA37161macie:sideChain
ThrA217341macie:sideChain

Annotated By Reference To The Literature - Site 2 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
AspB34158macie:sideChain
AspB214338macie:sideChain
SerB37161macie:sideChain
ThrB217341macie:sideChain

Literature References

Notes:
Silva AM
Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
Proc Natl Acad Sci U S A 1996 93 10034-10039
PubMed: 8816746
Silva AM
Structural analysis of plasmepsin II. A comparison with human aspartic proteases.
Adv Exp Med Biol 1998 436 363-373
PubMed: 9561243
Andreeva NS
Analysis of crystal structures of aspartic proteinases: on the role of amino acid residues adjacent to the catalytic site of pepsin-like enzymes.
Protein Sci 2001 10 2439-2450
PubMed: 11714911
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