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Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 1pkn

E.C. namepyruvate kinase
SpeciesOryctolagus cuniculus (Rabbit)
E.C. Number (IntEnz) 2.7.1.40
CSA Homologues of 1pknThere are 34 Homologs
CSA Entries With UniProtID P11974
CSA Entries With EC Number 2.7.1.40
PDBe Entry 1pkn
PDBSum Entry 1pkn
MACiE Entry M0326

Literature Report

Introduction
MechansimThe reaction of pyruvate kinase is a two step reaction. In the first reaction the phosphate group of PEP is transferred to ADP to produce ATP. The bound enol is then protonated to produce pyruvate in its keto form.
Reaction

Catalytic Sites for 1pkn

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
LysA269270macie:sideChain
SerA361362macie:sideChain
ArgA119120macie:sideChain
GluA363364macie:sideChain
ArgA7273macie:sideChain
ThrA327328macie:sideChain

Literature References

Notes:
Larsen TM
Structure of rabbit muscle pyruvate kinase complexed with Mn2+, K+, and pyruvate.
Biochemistry 1994 33 6301-6309
PubMed: 8193145
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