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Search The CSA
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Catalytic Site Atlas

CSA LITERATURE entry for 1pfq

E.C. namedipeptidyl-peptidase IV
SpeciesHomo sapiens (Human)
E.C. Number (IntEnz) 3.4.14.5
CSA Homologues of 1pfqThere are 140 Homologs
CSA Entries With UniProtID P27487
CSA Entries With EC Number 3.4.14.5
PDBe Entry 1pfq
PDBSum Entry 1pfq
MACiE Entry M0169

Literature Report

Introduction
Mechansim

Catalytic Sites for 1pfq

Annotated By Reference To The Literature - Site 1 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
HisA740740macie:sideChain
AspA708708macie:sideChain
SerA630630macie:sideChain

Annotated By Reference To The Literature - Site 2 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
HisB740740macie:sideChain
AspB708708macie:sideChain
SerB630630macie:sideChain

Literature References

Notes:
David F
Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases.
J Biol Chem 1993 268 17247-17252
PubMed: 8102366
Oefner C
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrolidine.
Acta Crystallogr D Biol Crystallogr 2003 59 1206-1212
PubMed: 12832764
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