spacer
View the latest EBI news stories and important announcements...
more

spacer
Search The CSA
PDB ID
UNIPROT ID
EC Number

Catalytic Site Atlas

CSA LITERATURE entry for 1bhg

E.C. namebeta-glucuronidase
SpeciesHomo sapiens (Human)
E.C. Number (IntEnz) 3.2.1.31
CSA Homologues of 1bhgThere are 41 Homologs
CSA Entries With UniProtID P08236
CSA Entries With EC Number 3.2.1.31
PDBe Entry 1bhg
PDBSum Entry 1bhg
MACiE Entry 1bhg

Literature Report

Introduction
Mechansim
Reaction

Catalytic Sites for 1bhg

Annotated By Reference To The Literature - Site 3 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
TyrA504504macie:sideChain
GluA540540macie:sideChain
GluA451451macie:sideChain

Annotated By Reference To The Literature - Site 4 (Perform Site Search)
ResidueChainNumberUniProtKB NumberFunctional PartFunctionTargetDescription
TyrB504504macie:sideChain
GluB540540macie:sideChain
GluB451451macie:sideChain

Literature References

Notes:
Jain S
Structure of human beta-glucuronidase reveals candidate lysosomal targeting and active-site motifs.
Nat Struct Biol 1996 3 375-381
PubMed: 8599764
Wong AW
Identification of Glu-540 as the catalytic nucleophile of human beta-glucuronidase using electrospray mass spectrometry.
J Biol Chem 1998 273 34057-34062
PubMed: 9852062
Islam MR
Active site residues of human beta-glucuronidase. Evidence for Glu(540) as the nucleophile and Glu(451) as the acid-base residue.
J Biol Chem 1999 274 23451-23455
PubMed: 10438523
spacer
spacer