Pfam
Pfam is a database of protein sequence families. Each Pfam family is represented by a statistical model, known as a profile hidden Markov model, which is trained using a curated alignment of representative sequences. These models can be searched against all protein sequences in order to find occurrences of Pfam families, thereby aiding the identification of evolutionarily-related (or homologous) sequences. As homologous proteins are more likely to share structural and functional features, Pfam families can aid in the annotation of uncharacterised sequences and guide experimental work.
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