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The International Mouse Phenotyping Consortium (IMPC) has initiated a global effort to generate and characterize a knockout mouse strain for every protein-coding gene in the mouse genome. The IMPC Informatics resource coordinates production of mouse strains, harmonises protocols and data export across centers, associates genes to phenotypes using an automated statistical pipeline, and performs data integration to gain new insights into human disease. Data is annotated to widely used ontologies, archived at EMBL-EBI using robust relational database structures and is freely available via an intuitive browser and a planned API.