## Term: SBO:0000262

### Name

enzymatic rate law for simple uncompetitive inhibition of irreversible unireactant enzymes### Definition

Inhibition of a unireactant enzyme by one inhibitor that binds only to the complex enzyme-substrate and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions.

### Synonym(s)

- simple linear uncompetitive inhibition

### MathML

<math xmlns="http://www.w3.org/1998/Math/MathML"> <semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062"> <lambda> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000505">Et</ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S</ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000521">I</ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar> <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar> <apply> <divide/> <apply> <times/> <ci>kcat</ci> <ci>Et</ci> <ci>S</ci> </apply> <apply> <plus/> <apply> <times/> <ci>S</ci> <apply> <plus/> <cn type="integer">1</cn> <apply> <divide/> <ci>I</ci> <ci>Ki</ci> </apply> </apply> </apply> <ci>Ks</ci> </apply> </apply> </lambda> </semantics> </math>

### Rendered equation

### Parent(s)

- SBO:0000458 enzymatic rate law for simple uncompetitive inhibition of reversible unireactant enzymes (is a)

### Miscellaneous

Date of creation: 10 November 2006, 23:12

Date of last modification: 05 February 2010, 11:43