Term: SBO:0000262

Name

enzymatic rate law for simple uncompetitive inhibition of irreversible unireactant enzymes

Definition

Inhibition of a unireactant enzyme by one inhibitor that binds only to the complex enzyme-substrate and totally prevent the catalysis. The enzymes do not catalyse the reactions in both directions.

Synonym(s)

MathML

<math xmlns="http://www.w3.org/1998/Math/MathML">
<semantics definitionURL="http://biomodels.net/SBO/#SBO:0000062">
   <lambda>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000505">Et</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000521">I</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000027">Ks</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000261">Ki</ci></bvar>
     <apply>
       <divide/>
       <apply>
         <times/>
         <ci>kcat</ci>
         <ci>Et</ci>
         <ci>S</ci>
       </apply>
       <apply>
         <plus/>
         <apply>
           <times/>
           <ci>S</ci>
           <apply>
             <plus/>
             <cn type="integer">1</cn>
             <apply>
               <divide/>
               <ci>I</ci>
               <ci>Ki</ci>
             </apply>
           </apply>
         </apply>
         <ci>Ks</ci>
       </apply>
     </apply>
   </lambda>
</semantics>
</math>

Rendered equation

graphical display of this term math

Parent(s)

Miscellaneous

Date of creation: 10 November 2006, 23:12
Date of last modification: 05 February 2010, 11:43

History [+]