Term: SBO:0000190

Name

Hill coefficient

Definition

Empirical parameter created by Archibald Vivian Hill to describe the cooperative binding of oxygen on hemoglobine (Hill (1910). The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves. J Physiol 40: iv-vii).

Comment

Determined from a "Hill plot", it is sometimes assumed to be the number of binding or catalytic sites in a polymer, but it is incorrect. In some mechanistic model, the Hill coefficient gives a lower limit for the number of sites.

Parent(s)

Miscellaneous

Date of creation: 03 August 2006, 18:35
Date of last modification: 25 November 2008, 16:09

History [+]