Term: SBO:0000029

Name

Henri-Michaelis-Menten rate law

Definition

First general rate equation for reactions involving enzymes, it was presented in "Victor Henri. Lois Générales de l'Action des Diastases. Paris, Hermann, 1903.". The reaction is assumed to be made of a reversible of the binding of the substrate to the enzyme, followed by the breakdown of the complex generating the product. Ten years after Henri, Michaelis and Menten presented a variant of his equation, based on the hypothesis that the dissociation rate of the substrate was much larger than the rate of the product generation. Leonor Michaelis, Maud Menten (1913). Die Kinetik der Invertinwirkung, Biochem. Z. 49:333-369.

MathML

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   <lambda>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000025">kcat</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000505">Et</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000515">S</ci></bvar>
     <bvar><ci definitionURL="http://biomodels.net/SBO/#SBO:0000373">Ks</ci></bvar>
     <apply>
       <divide/>
       <apply>
         <times/>
         <ci>kcat</ci>
         <ci>Et</ci>
         <ci>S</ci>
       </apply>
       <apply>
         <plus/>
         <ci>Ks</ci>
         <ci>S</ci>
       </apply>
     </apply>
   </lambda>
</semantics>
</math>

Rendered equation

graphical display of this term math

Parent(s)

Miscellaneous

Date of creation: 23 February 2006, 13:58
Date of last modification: 12 March 2010, 20:46

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