Saez-Rodriguez Group - Systems Biomedicine

The goal of the Saez-Rodriguez group is to acquire a functional understanding of signaling networks and their deregulation in disease and to apply this knowledge to novel therapeutics. Our research is hypothesis-driven and tailored towards producing mathematical models that integrate diverse data sources. To this end, we collaborate closely with experimental groups.

Our models integrate diverse types of data (from genomic to biochemical) with various sources of prior knowledge, with an emphasis on providing both predictive power of new experiments and insight on the functioning of the signaling network. We combine statistical methods with models describing the mechanisms of signal transduction either as logical or physico-chemical systems. Toward this end, we develop tools and integrate them with existing resources. We then use these models to better understand how signalling is altered in human disease and predict effective therapeutic targets.

The Saez-Rodriguez group is headed by Julio Saez-Rodriguez.