Gene & protein summary for O55143
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle
Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
GO Cellular Components
GO Biological Processes
cellular calcium ion homeostasis; ER-nucleus signaling pathway; negative regulation of heart contraction; (2 more)
View all in UniProt
GO Molecular Functions
Evidence at protein level
1 binary interaction was found. This protein interacts with 2 molecules reported by 2 experiments in 3 publications.
View all in IntAct
UniProt Data Source, 2013.12
UniProt is a comprehensive, high-quality and freely accessible resource for protein sequences and functional information.
View more information in UniProt