Search for Q9EQH2

Term identified:
Q9EQH2
Classification:
house mouse
Mus musculus

Gene

Endoplasmic reticulum aminopeptidase 1

Gene Information and Sequence
Variations
Orthologues
Paralogues
Regulation
  • The Ensembl project produces genome databases for vertebrates and other eukaryotic species, and makes this information freely available online.
  • The current release 76 ( August 2014 ) of the Ensembl provides access to the genomic, comparative, functional and variation data from 68 species.
  • View more information in Ensembl.

Expression

Erap1 expression summary

organism part
  • Not studied or no differential expression found for this gene
  • View all
disease
  • synovial sarcoma, tuberculosis, influenza
  • View all
cell type
  • Not studied or no differential expression found for this gene
  • View all
cell line
  • Not studied or no differential expression found for this gene
  • View all
Compound treatment
  • dinitrofluorobenzene, none, dibenzazepine 10 micromoles per kilogram, palmitate 500 micromolar
  • View all
developmental stage
  • Not studied or no differential expression found for this gene
  • View all
Infection
  • Trypanosoma brucei TREU927, Trypanosoma brucei STIB247, Plasmodium berghei
  • View all
phenotype
  • Not studied or no differential expression found for this gene
  • View all
  • Data source: Expression Atlas (12-11-2013).
  • Expression Atlas is a semantically enriched database of publicly available gene and transcript expression data. The data is re-analysed in-house to detect genes showing interesting baseline and differential expression patterns under the conditions of the original experiment.
  • About Expression Atlas

Protein

Endoplasmic reticulum aminopeptidase 1

Function
  • Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney
Subcellular Location
  • Endoplasmic reticulum membrane; Single-pass type II membrane protein (By similarity)
GO Cellular Components
GO Biological Processes
GO Molecular Functions
Protein Existence
  • Evidence at transcript level
Isoform
  • No isoforms available
Sequence
Family Classification
  • UniProt Data Source, 2014.08
  • UniProt is a comprehensive, high-quality and freely accessible resource for protein sequences and functional information.
  • View more information in UniProt

Protein Structure

No protein structure references have been found

Literature

These articles contain the gene or protein name in the title, abstract or keyword. They are ordered by date of publication with the most recent first. Citations are supported by CiteXplore, which includes all of PubMed (updated daily), Agricola, patents, PubMed Central and a selection of biomedical theses and reports.
All Articles (175)

  1. García-Medel N, Sanz-Bravo A, Alvarez-Navarro C, Gómez-Molina P, Barnea E, Marcilla M, Admon A and López de Castro JA
    Molecular & cellular proteomics : MCP Sep 2014
  2. Robinson PC, Claushuis TA, Cortes A, Martin TM, Evans DM, Leo P, Mukhopadhyay P, Bradbury LA, Cremin K, Harris J, Maksymowych WP, Inman RD, Rahman P, Haroon N, Gensler L, Powell JE, vanderHorst-Bruinsma IE, Hewitt AW, Craig JE, Lim LL, Wakefield D, McCluskey P, Voigt V, Fleming P, Degli-Esposti M, Pointon JJ, Weisman MH, Wordsworth BP, Reveille JD, Rosenbaum JT and Brown MA
    Arthritis & rheumatology (Hoboken, N.J.) Sep 2014
  3. Rastall DP, Aldhamen YA, Seregin SS, Godbehere S and Amalfitano A
    International immunology Aug 2014
View all 175 in Europe PubMed Central

These articles are reviews only. They have been selected because they have the gene or protein name in the title, abstract or keyword. They are ordered by date of publication with the most recent first. Citations are supported by CiteXplore, which includes all of PubMed (updated daily), Agricola, patents, PubMed Central and a selection of biomedical theses and reports.
Reviews (33)

  1. Shastri N, Nagarajan N, Lind KC and Kanaseki T
    Current opinion in immunology 26 Feb 2014
  2. Gül A
    Current opinion in rheumatology 26(1) Jan 2014
  3. Alvarez-Navarro C and López de Castro JA
    Molecular immunology 57(1) Jan 2014
View all 33 in Europe PubMed Central

These articles contain the gene or protein name in the title. They are ordered by publication date, with the most recent first. Citations are supported by CiteXplore, which includes all of PubMed (updated daily), Agricola, patents, PubMed Central and a selection of biomedical theses and reports.
Title Contains "Erap1" (55)

  1. García-Medel N, Sanz-Bravo A, Alvarez-Navarro C, Gómez-Molina P, Barnea E, Marcilla M, Admon A and López de Castro JA
    Molecular & cellular proteomics : MCP Sep 2014
  2. Rastall DP, Aldhamen YA, Seregin SS, Godbehere S and Amalfitano A
    International immunology Aug 2014
  3. Evnouchidou I, Weimershaus M, Saveanu L and van Endert P
    Journal of immunology (Baltimore, Md. : 1950) 193(2) Jul 2014
View all 55 in Europe PubMed Central

These articles are supplied by UK PubMed Central and are free to access from anywhere in the world. They have been selected because they have the gene or protein name in the title, abstract or keyword. They are ordered by date of publication with the most recent first. Citations are supported by CiteXplore, which includes all of PubMed (updated daily), Agricola, patents, PubMed Central and a selection of biomedical theses and reports.
Free Full Text Articles (58)

  1. Conde-Jaldón M, Montes-Cano MA, García-Lozano JR, Ortiz-Fernández L, Ortego-Centeno N, González-León R, Espinosa G, Graña-Gil G, Sánchez-Bursón J, González-Gay MA, Barnosi-Marín AC, Solans R, Fanlo P, Carballeira MR, Camps T, Castañeda S, Martín J and González-Escribano MF
    PloS one 9(7) 2014
  2. Haram K, Mortensen JH and Nagy B
    Journal of pregnancy 2014 2014
  3. Tsui FW, Tsui HW, Akram A, Haroon N and Inman RD
    The application of clinical genetics 7 2014
View all 58 in Europe PubMed Central

These articles have been selected by curators of gene and protein databases such as UniProt. If your search found a hit in UniProt, then the reference list from that record is displayed below
Curator-Selected Articles for "Erap1" (23)

  1. Goto Y, Ogawa K, Nakamura TJ, Hattori A and Tsujimoto M
    Journal of immunology (Baltimore, Md. : 1950) 192(9) May 2014
  2. Zervoudi E, Saridakis E, Birtley JR, Seregin SS, Reeves E, Kokkala P, Aldhamen YA, Amalfitano A, Mavridis IM, James E, Georgiadis D and Stratikos E
    Proceedings of the National Academy of Sciences of the United States of America 110(49) Dec 2013
  3. Kanaseki T, Lind KC, Escobar H, Nagarajan N, Reyes-Vargas E, Rudd B, Rockwood AL, Van Kaer L, Sato N, Delgado JC and Shastri N
    Journal of immunology (Baltimore, Md. : 1950) 191(4) Aug 2013
View all 23 in Europe PubMed Central
  • Europe PubMed Central is a database of over 28 million citations, incorporating PubMed, Agricola, and Patent information, and over 2.6 million full text research articles, of which 570K are Open Access. It is updated daily, and is enriched by text-mined terms, links to databases at the EBI, as well as information on who is citing who in the biomedical literature.
  • Europe PubMed Central