Search for Q9EQH2

Term identified:
Q9EQH2
Classification:
house mouse
Mus musculus

Gene

17 genes available
ENSMUSG00000021583ENSMUSG00000021583 (MGI: Erap1)
MGP_C57BL6NJ_G0021157MGP_C57BL6NJ_G0021157 (MGI: Erap1)
MGP_CASTEiJ_G0020032MGP_CASTEiJ_G0020032 (MGI: Erap1)
MGP_PWKPhJ_G0019785MGP_PWKPhJ_G0019785 (MGI: Erap1)
MGP_CBAJ_G0020473MGP_CBAJ_G0020473 (MGI: Erap1)
MGP_AKRJ_G0020697MGP_AKRJ_G0020697 (MGI: Erap1)
MGP_C3HHeJ_G0020514MGP_C3HHeJ_G0020514 (MGI: Erap1)
MGP_129S1SvImJ_G0020768MGP_129S1SvImJ_G0020768 (MGI: Erap1)
MGP_NODShiLtJ_G0020607MGP_NODShiLtJ_G0020607 (MGI: Erap1)
MGP_AJ_G0020723MGP_AJ_G0020723 (MGI: Erap1)
MGP_NZOHlLtJ_G0021197MGP_NZOHlLtJ_G0021197 (MGI: Erap1)
MGP_WSBEiJ_G0020089MGP_WSBEiJ_G0020089 (MGI: Erap1)
MGP_FVBNJ_G0020578MGP_FVBNJ_G0020578 (MGI: Erap1)
MGP_LPJ_G0020671MGP_LPJ_G0020671 (MGI: Erap1)
MGP_DBA2J_G0020598MGP_DBA2J_G0020598 (MGI: Erap1)
MGP_BALBcJ_G0020720MGP_BALBcJ_G0020720 (MGI: Erap1)
MGP_SPRETEiJ_G0019608MGP_SPRETEiJ_G0019608 (MGI: Erap1)
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Expression

Erap1 expression summary

organism part
disease
  • tuberculosis, synovial sarcoma, alopecia areata, TMEV infected
  • View all
cell type
  • extraembryonic endoderm stem cell, proerythroblast, podocyte, granulocyte, basophilic erythroblast, neuron, induced extraembryonic endoderm stem cell
  • View all
cell line
Compound treatment
  • dinitrofluorobenzene, ciliary neurotrophic factor, human chorionic gonadotropin 5 International Unit, Tetrafluororethane 50000 part per million, butyrate, doxorubicin 17.5 milligram per kilogram body weight
  • View all
developmental stage
  • Not studied or no differential expression found for this gene
  • View all
Infection
phenotype
  • adult definitive erythroid cell, reduced expression of miR-25
  • View all
  • Data source: Expression Atlas (12-11-2013).
  • Expression Atlas is a semantically enriched database of publicly available gene and transcript expression data. The data is re-analysed in-house to detect genes showing interesting baseline and differential expression patterns under the conditions of the original experiment.
  • About Expression Atlas

Protein

Endoplasmic reticulum aminopeptidase 1

Subcellular Location
Function
  • Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney (By similarity).
  • View annotation in UniProt
GO Cellular Component
  • cytoplasm; endoplasmic reticulum membrane; extracellular exosome; (4 more)
  • View all in UniProt
GO Molecular Function
  • aminopeptidase activity; endopeptidase activity; interleukin-6 receptor binding; (5 more)
  • View all in UniProt
GO Biological Process
  • adaptive immune response; antigen processing and presentation of endogenous peptide antigen via MHC class I; cell-cell signaling; (6 more)
  • View all in UniProt
Isoform
  • No isoforms available
Protein Existence
  • Evidence at protein level
Sequence
Family Classification
  • UniProt Data Source, 2017_04
  • UniProt is a comprehensive, high-quality and freely accessible resource for protein sequences and functional information.
  • View more information in UniProt

Protein Structure

No protein structure references have been found

Literature

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