Search for Q61091

Term identified:
Q61091
Classification:
house mouse
Mus musculus

Gene

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Expression

Fzd8 expression summary

organism part
  • Not studied or no differential expression found for this gene
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disease
cell type
  • extensive self renewing erythroblast, induced neural stem cell
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cell line
Compound treatment
  • cadmium 20 micromole per kilogram, Methylene Chloride 4000 part per million, Malathion 14800 part per million
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developmental stage
  • Not studied or no differential expression found for this gene
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Infection
phenotype
  • Yin Yang 1 adipose tissue specific deletion
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  • Data source: Expression Atlas (12-11-2013).
  • Expression Atlas is a semantically enriched database of publicly available gene and transcript expression data. The data is re-analysed in-house to detect genes showing interesting baseline and differential expression patterns under the conditions of the original experiment.
  • About Expression Atlas

Protein

Frizzled-8

Subcellular Location
  • Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with GOPC at the Golgi apparatus.
  • View annotation in UniProt
Function
  • Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes (By similarity). The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
  • View annotation in UniProt
GO Cellular Component
  • extracellular region; Golgi apparatus; integral component of membrane; (2 more)
  • View all in UniProt
GO Molecular Function
  • G-protein coupled receptor activity; PDZ domain binding; receptor binding; (3 more)
  • View all in UniProt
GO Biological Process
  • angiogenesis; canonical Wnt signaling pathway; negative regulation of transcription from RNA polymerase II promoter; (5 more)
  • View all in UniProt
Isoform
  • No isoforms available
Protein Existence
  • Evidence at protein level
Sequence
  • UniProt Data Source, 2016_05
  • UniProt is a comprehensive, high-quality and freely accessible resource for protein sequences and functional information.
  • View more information in UniProt

Protein Structure

2 protein structures available
1ijyCRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MOUSE FRIZZLED 8 (MFZ8)
4f0aCrystal structure of XWnt8 in complex with the cysteine-rich domain of Frizzled 8
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Literature

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