Systems biomedicine

The goal of our group is to acquire a functional understanding of the deregulation of signalling networks in disease and to apply this knowledge to novel therapeutics. This deregulation in how cell process and react to extracellular information is a hallmark of multiple pathological conditions. Our main application is cancer, but we also work on metabolic and auto-immune diseases.

Our research is hypothesis-driven and tailored towards producing mathematical models that integrate diverse data sources. Because of this, we collaborate closely with experimental groups. A key emphasis of our work is to build models that are both mechanistic (to provide understanding) and predictive (to generate novel hypotheses). To build these models, we combine the existing knowledge of the underlying biochemical processes with functional signalling data. In parallel, we study drugs’ modes of action by analysing genomic and phenotypic data collected in large-scale drug screenings. We then strive to combine this information with our prior knowledge of the underlying pathways to ultimately build integrated mechanistic models. Our premise is that these will have enhanced ability to discern the mode of action of existing therapies and provide avenues for the development of new drugs.

Productive integration of data and computation requires an effective workflow that pulls together all the steps that link experiments to mathematical models and analysis. We therefore strive to develop tools that facilitate this process and incorporate public standards. We are also involved in a community effort to advance the inference of mathematical models of cellular networks: DREAM (Dialogue for Reverse Engineering Assessments and Methods).

With these methods we hope to address questions such as:

  • What are the origins of the profound differences in signal transduction between healthy and diseased cells and in particular, in the context of cancer, between normal and transformed cells?
  • What are the differences in signal transduction among cancer types, and from patient to patient? Can we use these differences to predict disease progression?
  • Do these differences reveal valuable targets for drug development? Can we study the side effects of drugs using these models?

Saez-Rodriguez group (EMBL-EBI)

An illustration of how we use our logic modelling method CellNOpt to better understand deregulation of signal transduction in disease. Left: simple pathway model; right: experimental data and match between model simulations and data.

Job Opportunities

Postdoctoral positions

We do not have any open position at the moment. Please contact us if you would like to apply for a fellowship with our group as your host, including a project proposal.

PhD studentships

We participate in the EMBL Interntional PhD Programme. Please check to see which EMBL-EBI groups are recruiting in the current round, and the guidelines for application for deadlines and requirements.

Internships

We host interns for projects lasting at least five months. Contact us at internships-sbm@ebi.ac.uk, explaining the project you are interested in, and why it interests you. We will not consider non-specific applications without this expression of interest, or that are sent to another e-mail address.

Postdocs

EBPOD postdoctoral programme

Saez-Rodriguez group news