A User's Guide to the Encyclopedia of DNA Elements (ENCODE).

TitleA User's Guide to the Encyclopedia of DNA Elements (ENCODE).
Publication TypeJournal Article
Year of Publication2011
AuthorsConsortium ENCODE P
JournalPLoS Biol
Volume9
Paginatione1001046
Date Published4
ISSN1545-7885
KeywordsBase Sequence, Chromatin, Conserved Sequence, Databases, DNA Methylation, DNA-Binding Proteins, extramural, Gene Components, Gene Expression Regulation, Genetic, Genome, Human, Humans, Internet, Messenger, Models, n.i.h., Nucleic Acid, Quality Control, research support, RNA, RNA-Binding Proteins
AbstractThe mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the scientific and medical communities to interpret the human genome sequence and apply it to understand human biology and improve health. The ENCODE Consortium is integrating multiple technologies and approaches in a collective effort to discover and define the functional elements encoded in the human genome, including genes, transcripts, and transcriptional regulatory regions, together with their attendant chromatin states and DNA methylation patterns. In the process, standards to ensure high-quality data have been implemented, and novel algorithms have been developed to facilitate analysis. Data and derived results are made available through a freely accessible database. Here we provide an overview of the project and the resources it is generating and illustrate the application of ENCODE data to interpret the human genome.
DOI10.1371/journal.pbio.1001046