TitleTranscriptional data: a new gateway to drug repositioning?
Publication TypeJournal Article
Year of Publication2013
AuthorsIORIO F., Rittman T., Ge H., MENDEN M, SAEZ-RODRIGUEZ J
JournalDrug discovery today
Volume18
Pagination350-357
Date PublishedAug 7
ISBN Number1878-5832; 1359-6446
AbstractRecent advances in computational biology suggest that any perturbation to the transcriptional programme of the cell can be summarised by a proper 'signature': a set of genes combined with a pattern of expression. Therefore, it should be possible to generate proxies of clinicopathological phenotypes and drug effects through signatures acquired via DNA microarray technology. Gene expression signatures have recently been assembled and compared through genome-wide metrics, unveiling unexpected drug-disease and drug-drug 'connections' by matching corresponding signatures. Consequently, novel applications for existing drugs have been predicted and experimentally validated. Here, we describe related methods, case studies and resources while discussing challenges and benefits of exploiting existing repositories of microarray data that could serve as a search space for systematic drug repositioning.
URLhttp://dx.doi.org/10.1016/j.drudis.2012.07.014