The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.

TitleThe International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Publication TypeJournal Article
Year of Publication2013
AuthorsKoscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen C-K, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SDM, Flicek P, Skarnes WC, Mallon A-M, Parkinson H
JournalNucleic acids research
ISSN1362-4962
AbstractThe International Mouse Phenotyping Consortium (IMPC) web portal (http://www.mousephenotype.org) provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease. As phenotype data become available for every gene in the mouse, the IMPC web portal will become an invaluable tool for researchers studying the genetic contributions of genes to human diseases.
URLhttp://www.ncbi.nlm.nih.gov/pubmed/24194600
DOI10.1093/nar/gkt977