International PhD Programme research topics

When you apply for the EMBL International PhD Programme, you are asked to select two EMBL research groups and to indicate up to four research areas that interest you. A variety of backgrounds - such as biology, chemistry, computational science, mathematics and statistics - are relevant to PhD projects at EMBL-EBI. As well as purely computational projects, there may also be possibilities to incorporate some experimental biology in collaborating laboratories.

Here, we show research groups that are currently accepting PhD students at EMBL-EBI. You can find other EMBL research units on the EMBL website, and browse all EMBL research groups in our Research at a Glance brochure.

Flicek research group

Evolution of transcriptional regulation

Dr Paul Flicek's research group focuses on computational models for genome annotation and evolution based on models incorporating DNA-protein interactions, epigenetic modifications, and the DNA sequence itself. The group is also interested in the large-scale infrastructure required for modern bioinformatics including storage and access methods for high-throughput sequencing data.

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Marioni research group

Computational and evolutionary genomics

Dr John Marioni's research group develops effective statistical and computational methods for analysing the vast amounts of data generated in high-throughput experiments. To gain a deeper understanding of complex biological processes such as gene regulation, the group develops computational methods for interrogating high-throughput genomics data. Their work focuses primarily on modelling variation in gene expression levels in different contexts: between individual cells from the same tissue; across different samples taken from the same tumour; and at the population level where a single, large sample of cells is taken from the organism and tissue of interest. Working with experimental colleagues within and beyond EMBL, the group applies their methods to biological questions ranging from the regulation of mammalian gene expression levels to the brain development in a marine annelid.

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Teichmann research group

Gene expression regulation and protein complex assembly

Dr Sarah Teichmann's research group seeks to elucidate general principles of gene expression and protein complex assembly. They study protein complexes in terms of their three-dimensional structure, structure evolution, and the principles underlying protein complex formation and organization. Another major focus is understanding regulation of gene expression during switches in cell state, and in their wet lab at the Wellcome Trust Sanger Institute the group uses mouse T-helper cells as a model of cell differentiation.

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