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Research at the EBI
EMBL-EBI is probably best known worldwide for its provision of biological information and bioinformatics services. However, about 20% of the institute is devoted to investigator-led research using computational approaches to unravel the secrets of life. Research at EMBL-EBI is carried out both in groups devoted solely to research and in some of the larger service teams that have associated research activities. All researchers have computational approaches as their major focus, but most also collaborate closely with experimentalists and often generate experimental data themselves.
Rolf Apweiler - Joint Associate DirectorPanda ProteinsThis part of the Panda group is in charge of data resources related to the protein sequence, domains and families database resources. Paul Bertone - Group LeaderBertone GroupThe group applies bioinformatics and functional genomics to study early developmental pathways, with a particular focus on lineage commitment and differentiation of mammalian embryonic and neural stem cells. Ewan Birney - Joint Associate DirectorPanda NucleotidesThis part of the Panda group is in charge of the nucleotide sequence databases at the EBI that include ENSEMBL, EMBL-Bank and ASTD. Alvis Brazma - Team LeaderMicroarray GroupGene expression data analysis, gene network and function inference from microarray data, functional genomics data integration, analysis and visualisation, biomedical informatics. Anton Enright - Group Leader Enright GroupEnright GroupThis group will focus on a number of problems relating to the prediction of the functions of genes and proteins in living organisms. Paul Flicek - Team LeaderVertebrate Genomics TeamThe group's research focuses on functional annotation of the genome including methods for incorporating high-throughput epigenetic data for expanding and understanding the collection of human variation. Gerard Kleywegt - Group LeaderProtein Data Bank in Europe (PDBe)This group aims to improve the consistency and quality of the world archive of data on macromolecular structures by integrating current database and informatics technologies with a solid core of expertise in structural biology. Nick Goldman - Group LeaderGoldman GroupNick Goldman's group studies statistical methods for the analysis of DNA and amino acid sequences, to study evolution and to exploit evolutionary relationships to better understand the function of genome regions. Wolfgang Huber - Group LeaderHuber Group (based in EMBL Heidelberg but working in close association with the EBI)The group studies genotypes and phenotypes on a genome-wide scale: how do variations in the genomes of individuals shape their complex phenotypes? To this end, we develop computational methods in statistics, signal and image processing, probability models. Nicolas Le Novère - Group LeaderComputational Neurobiology GroupThe interests of the group Computational Neurobiology revolve around signal transduction in neurons, ranging from the molecular structure of membrane proteins involved in neurotransmission to modelling signalling pathways. Nick Luscombe - Group LeaderLuscombe GroupThe group studies biological regulatory systems on a genomic scale: our current focus is to examine how the biology of an organism is shaped by regulation of gene expression. We investigate this at various levels of complexity, from single-celled bacteria and yeast, to mammals by integrating disparate sources of data. John Marioni - Group LeaderMarioni GroupThe group's research is motivated by a desire to understand how changes in genetic architecture (e.g. the relationship between sequence and gene expression) can provide insights into the evolution of primates and other mammals. Recent technological developments, such as next-generation sequencing, have led to enormous increases in the amount of data that can be used to help us identify and interpret these changes - with this in mind, our work focuses on the development of statistical methods that will exploit these data to the fullest extent. John Overington - Team LeaderChEMBL TeamThe ChEMBL team's research focuses on mapping the interactions and functional effects of small molecules binding to their macromolecular targets. Dietrich Rebholz-Schuhmann - Group LeaderRebholz GroupRebholz group studies extraction of facts from scientific literature, develops new language processing and statistical methods in conjunction with bioinformatics data resources. Julio Saez-Rodriguez- Group LeaderSaez-Rodriguez groupThe group is interested in how the dynamics of signal transduction ultimately influence cell fate decisions. Specifically, the group’s research aims to combine statistical methods with models describing the mechanisms of signal transduction either as logical or physico-chemical systems. They then use these models to better understand how signalling is altered in human disease and predict effective therapeutic targets. Christoph Steinbeck- Team LeaderSteinbeck Research TeamThe Steinbeck team's research in molecular informatics focuses on the understanding of the small-molecule metabolism of living organism, including methods for computer-assisted structure elucidation of biological metabolites and simulations of metabolic pathways. Janet Thornton - EBI DirectorThornton GroupThe group analyses the three dimensional structural basis of protein function and its evolution. We focus on enzyme catalysis, molecular recognition and drug design and the molecular basis of ageing. |
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