PDBsum entry 8h77

Cytosolic protein

PDB id: 8h77

Contents

Protein chains

636 a.a.

113 a.a.

140 a.a.

310 a.a.

Ligands

ADP-BEF ×2

PDB id:

8h77

Name:

Cytosolic protein

Title:

Hsp90-ahr-p23-xap2 complex

Structure:

Heat shock protein hsp 90-beta. Chain: a, b. Synonym: heat shock 84 kda,hsp 84,hsp84,tumor-specific transplantation 84 kda antigen,tsta. Engineered: yes. Prostaglandin e synthase 3. Chain: c, d. Synonym: cytosolic prostaglandin e2 synthase,cpges,hsp90 co- chaperone,progesterone receptor complex p23,sid 3177,telomerase-

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: hsp90ab1, hsp84, hsp84-1, hspcb. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ptges3, sid3177, tebp. Gene: ahr. Gene: aip.

Authors:

Z.L.Wen,Y.J.Zhai,Y.Zhu,F.Sun

Key ref:

Z.Wen et al. Cryo-Em structure of the cytosolic ahr complex.. Structure, . PubMed id: 36649707

Date:

19-Oct-22 Release date: 04-Jan-23

Protein chains

P11499  (HS90B_MOUSE) -  Heat shock protein HSP 90-beta from Mus musculus

Seq: 724 a.a.

Struc: 636 a.a.

Protein chains

Q9R0Q7  (TEBP_MOUSE) -  Prostaglandin E synthase 3 from Mus musculus

Seq: 160 a.a.

Struc: 113 a.a.

Protein chain

P30561  (AHR_MOUSE) -  Aryl hydrocarbon receptor from Mus musculus

Seq: 848 a.a.

Struc: 140 a.a.

Protein chain

O08915  (AIP_MOUSE) -  AH receptor-interacting protein from Mus musculus

Seq: 330 a.a.

Struc: 310 a.a.

Enzyme reactions

• Enzyme class: Chains C, D: E.C.5.3.99.3 - prostaglandin-E synthase.
• Reaction: prostaglandin H2 = prostaglandin E2
• Cofactor: Glutathione

Molecule diagrams generated from .mol files obtained from the KEGG ftp site