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PDBsum entry 7ysh
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protein ligands metals Protein-protein interface(s) links
Signaling protein PDB id
7ysh

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
921 a.a.
179 a.a.
213 a.a.
Ligands
SGN-IDS-SGN-IDS-
SGN-IDS-SGN-IDS-
SGN
Metals
_ZN
_CU
PDB id:
7ysh
Name: Signaling protein
Title: Cryo-em structure of fgf23-fgfr1c-aklotho-hs quaternary complex
Structure: Klotho. Chain: a. Engineered: yes. Other_details: klotho co-receptor. Fibroblast growth factor 23. Chain: b. Synonym: fgf-23,phosphatonin,tumor-derived hypophosphatemia-inducing factor. Engineered: yes.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kl. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293s gnti-. Gene: fgf23, hypf, unq3027/pro9828. Expressed in: escherichia coli.
Authors: M.Mohammadi,L.Chen
Key ref: L.Chen and m.mohammadi Fgf hormones signal via dual co-Receptor dependent asymmetric fgf receptor dimers. To be published, . PubMed id: 37286607
Date:
12-Aug-22     Release date:   19-Apr-23    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Q9UEF7  (KLOT_HUMAN) -  Klotho from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		1012 a.a.
921 a.a.
Protein chain
Q9GZV9  (FGF23_HUMAN) -  Fibroblast growth factor 23 from Homo sapiens
Seq:
Struc: 		251 a.a.
179 a.a.*
Protein chains
P11362  (FGFR1_HUMAN) -  Fibroblast growth factor receptor 1 from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		822 a.a.
213 a.a.
Key:    Secondary structure
* PDB and UniProt seqs differ at 2 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 1: Chain A: E.C.3.2.1.31  - beta-glucuronidase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: a beta-D-glucuronoside + H2O = D-glucuronate + an alcohol
beta-D-glucuronoside
 + H2O
 =
D-glucuronate
Bound ligand (Het Group name = IDS)
matches with 70.59% similarity 		+ alcohol
   Enzyme class 2: Chains D, E: E.C.2.7.10.1  - receptor protein-tyrosine kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
L-tyrosyl-[protein]
 + ATP
 = O-phospho-L-tyrosyl-[protein]
 + ADP
 + H(+)
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 

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