PDBsum entry 7l6c

Oxidoreductase

PDB id: 7l6c

Contents

Protein chains

267 a.a.

Ligands

NAD ×4

EDO ×2

Metals

_NA ×4

Waters ×891

PDB id:

7l6c

Name:

Oxidoreductase

Title:

Crystal structure of enoyl-[acyl-carrier-protein] reductase inha from mycobacterium abscessus in complex with NAD

Structure:

Enoyl-[acyl-carrier-protein] reductase [nadh]. Chain: a, b, c, d. Fragment: myaba.00170.A.B1. Engineered: yes

Source:

Mycobacteroides abscessus (strain atcc 19977 / dsm 44196 / cip 104536 / jcm 13569 / nctc 13031 / tmc 1543). Organism_taxid: 561007. Strain: atcc 19977 / dsm 44196 / cip 104536 / jcm 13569 / nctc 13031 / tmc 1543. Gene: mab_2722c. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.85Å R-factor: 0.190 R-free: 0.219

Authors:

Seattle Structural Genomics Center For Infectious Disease (Ssgcid)

Key ref:

J.A.Abendroth et al. Crystal structure of enoyl-[Acyl-Carrier-Protein] red inha from mycobacterium abscessus in complex with NAD. To be published, . PubMed id: 36107992

Date:

23-Dec-20 Release date: 13-Jan-21

Protein chains

B1MC30  (B1MC30_MYCA9) -  Enoyl-[acyl-carrier-protein] reductase [NADH] from Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CCUG 20993 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543 / L948)

Seq: 269 a.a.

Struc: 267 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.1.9 - enoyl-[acyl-carrier-protein] reductase (NADH).
• Reaction: a 2,3-saturated acyl-[ACP] + NAD⁺ = a (2E)-enoyl-[ACP] + NADH + H⁺

2,3-saturated acyl-[ACP] + NAD(+) (Bound ligand (Het Group name = NAD) corresponds exactly) = (2E)-enoyl-[ACP] + NADH + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site