PDBsum entry 7kjc

Transferase

PDB id: 7kjc

Contents

Protein chains

376 a.a.

350 a.a.

Ligands

ACP ×2

GOL ×4

Metals

_MG

Waters ×343

PDB id:

7kjc

Name:

Transferase

Title:

Crystal structure of the epha2 s901e mutant intracellular kd-sam domains

Structure:

Ephrin type-a receptor 2. Chain: a, b. Synonym: epithelial cell kinase,tyrosine-protein kinase receptor eck. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: epha2, eck. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.30Å R-factor: 0.190 R-free: 0.226

Authors:

B.C.Lechtenberg,E.B.Pasquale

Key ref:

B.C.Lechtenberg et al. Crystal structure of the epha2 s901e mutant intracell kd-Sam domains. To be published, . PubMed id: 34857764

Date:

26-Oct-20 Release date: 03-Feb-21

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 376 a.a.*

Protein chain

P29317  (EPHA2_HUMAN) -  Ephrin type-A receptor 2 from Homo sapiens

Seq: 976 a.a.

Struc: 350 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] (Bound ligand (Het Group name = ACP) matches with 81.25% similarity) + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site