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PDBsum entry 7apf
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PDB id:
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Transferase
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Title:
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Crystal structure of jak3 in complex with fm601 (compound 10a)
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Structure:
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Tyrosine-protein kinase jak3. Chain: a, b. Synonym: janus kinase 3,jak-3,leukocyte janus kinase,l-jak. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: jak3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108
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Resolution:
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1.95Å
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R-factor:
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0.206
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R-free:
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0.255
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Authors:
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A.Chaikuad,M.Forster,M.Gehringer,S.Laufer,S.Knapp,Structural Genomics Consortium (Sgc)
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Key ref:
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a.chaikuad
et al.
(2020).
Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.
Int J Mol Sci,
21,
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PubMed id:
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Date:
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16-Oct-20
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Release date:
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02-Dec-20
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PROCHECK
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Headers
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References
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P52333
(JAK3_HUMAN) -
Tyrosine-protein kinase JAK3 from Homo sapiens
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Seq:
Struc:
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1124 a.a.
290 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 3 residue positions (black
crosses)
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Enzyme class:
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E.C.2.7.10.2
- non-specific protein-tyrosine kinase.
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Reaction:
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L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H+
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L-tyrosyl-[protein]
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+
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ATP
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=
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O-phospho-L-tyrosyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Int J Mol Sci
21:
(2020)
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PubMed id:
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Discovery of a Novel Class of Covalent Dual Inhibitors Targeting the Protein Kinases BMX and BTK.
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a.chaikuad,
m.forster,
m.gehringer,
s.laufer,
s.knapp,
structural genomics consortium (sgc).
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ABSTRACT
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Links
