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PDBsum entry 6xjs
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protein ligands metals Protein-protein interface(s) links
Protein transport PDB id
6xjs

 

 

 

 

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Contents
Protein chains
208 a.a.
123 a.a.
1011 a.a.
Ligands
GNP
GOL ×2
V6A
Metals
_MG
Waters ×508
PDB id:
6xjs
Name: Protein transport
Title: Crystal structure of kpt-330 bound to crm1 (e582k, 537-dltvk-541 to glceq)
Structure: Gtp-binding nuclear protein ran. Chain: a. Synonym: androgen receptor-associated protein 24,gtpase ran,ras-like protein tc4,ras-related nuclear protein. Engineered: yes. Ran-specific gtpase-activating protein 1. Chain: b. Synonym: chromosome stability protein 20,perinuclear array-localized protein,ran-binding protein 1,ranbp1.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ran, ara24, ok/sw-cl.81. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932.
Resolution:
1.94Å     R-factor:   0.202     R-free:   0.240
Authors: J.M.Baumhardt,Y.M.Chook
Key ref: J.S.Walker et al. (2021). Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia. J Hematol Oncol, 14, 17. PubMed id: 33451349 DOI: 10.1186/s13045-021-01032-2
Date:
24-Jun-20     Release date:   27-Jan-21    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P62826  (RAN_HUMAN) -  GTP-binding nuclear protein Ran from Homo sapiens
Seq:
Struc: 		216 a.a.
208 a.a.
Protein chain
Pfam   ArchSchema ?
P41920  (YRB1_YEAST) -  Ran-specific GTPase-activating protein 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		201 a.a.
123 a.a.
Protein chain
Pfam   ArchSchema ?
P30822  (XPO1_YEAST) -  Exportin-1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		1084 a.a.
1011 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 6 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain A: E.C.3.6.5.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
DOI no: 10.1186/s13045-021-01032-2 J Hematol Oncol 14:17 (2021)
PubMed id: 33451349  
 
 
Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J.S.Walker, Z.A.Hing, B.Harrington, J.Baumhardt, H.G.Ozer, A.Lehman, B.Giacopelli, L.Beaver, K.Williams, J.N.Skinner, C.B.Cempre, Q.Sun, S.Shacham, B.R.Stromberg, M.K.Summers, L.V.Abruzzo, L.Rassenti, T.J.Kipps, S.Parikh, N.E.Kay, K.A.Rogers, J.A.Woyach, V.Coppola, Y.M.Chook, C.Oakes, J.C.Byrd, R.Lapalombella.
 
  ABSTRACT  
 
No abstract given.

 

 

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