PDBsum entry 6wc6

Oxidoreductase

PDB id: 6wc6

Contents

Protein chains

666 a.a.

133 a.a.

15 a.a.

Ligands

FAD

PDB id:

6wc6

Name:

Oxidoreductase

Title:

Crystal structure of a truncated lsd1:corest in the presence of an lsd1-nt peptide

Structure:

Lysine-specific histone demethylase 1a. Chain: a. Synonym: braf35-hdac complex protein bhc110,flavin-containing amine oxidase domain-containing protein 2. Engineered: yes. Rest corepressor 1. Chain: b. Synonym: protein corest. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kdm1a, aof2, kdm1, kiaa0601, lsd1. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: rcor1, kiaa0071, rcor. Expression_system_taxid: 469008

Resolution:

3.10Å R-factor: 0.217 R-free: 0.236

Authors:

N.J.Reiter,D.Zeng,D.Senanayaka

Key ref:

D.Zeng et al. Identification of structure and nucleosome binding wi the n-Terminus of lysine specific demethylase 1. To be published, .

Date:

29-Mar-20 Release date: 30-Jun-21

Protein chain

O60341  (KDM1A_HUMAN) -  Lysine-specific histone demethylase 1A from Homo sapiens

Seq: 852 a.a.

Struc: 666 a.a.

Protein chain

Q9UKL0  (RCOR1_HUMAN) -  REST corepressor 1 from Homo sapiens

Seq: 485 a.a.

Struc: 133 a.a.

Protein chain

O60341  (KDM1A_HUMAN) -  Lysine-specific histone demethylase 1A from Homo sapiens

Seq: 852 a.a.

Struc: 15 a.a.

Enzyme reactions

• Enzyme class: Chains A, C: E.C.1.14.99.66 - [histone-H3]-N(6),N(6)-dimethyl-L-lysine(4) FAD-dependent demethylase.
• Reaction: N₆,N₆-dimethyl-L-lysyl₄-[histone H3] + 2 A + 2 H2O = L-lysyl₄- [histone H3] + 2 formaldehyde + 2 AH2

Molecule diagrams generated from .mol files obtained from the KEGG ftp site