PDBsum entry 6w2c

Transport protein

PDB id: 6w2c

Contents

Protein chains

544 a.a.

218 a.a.

214 a.a.

Ligands

RFY

PDB id:

6w2c

Name:

Transport protein

Title:

Anomalous iodine signal reveals the position of i-paroxetine complexed with the serotonin transporter at the central site

Structure:

Sodium-dependent serotonin transporter. Chain: a. Fragment: unp residues 76-618. Synonym: sert,5ht transporter,5htt,solute carrier family 6 member 4. Engineered: yes. 8b6 heavy chain antibody fragment. Chain: b. Engineered: yes. 8b6 light chain antibody fragment.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: slc6a4, htt, sert. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293 gnti-. Mus musculus. Mouse.

Resolution:

6.30Å R-factor: 0.309 R-free: 0.370

Authors:

J.A.Coleman,V.Navratna,D.Yang

Key ref:

j.a.coleman et al. (2020). Chemical and structural investigation of the paroxetine-human serotonin transporter complex. Elife, 9, . PubMed id: 32618269

Date:

05-Mar-20 Release date: 25-Mar-20

Protein chain

P31645  (SC6A4_HUMAN) -  Sodium-dependent serotonin transporter from Homo sapiens

Seq: 630 a.a.

Struc: 544 a.a.*

Protein chain

No UniProt id for this chain

Struc: 218 a.a.

Protein chain

No UniProt id for this chain

Struc: 214 a.a.

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Elife 9: (2020)

PubMed id: 32618269

Chemical and structural investigation of the paroxetine-human serotonin transporter complex.

j.a.coleman, v.navratna, d.antermite, d.yang, j.bull, e.go.

ABSTRACT

No abstract given.