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PDBsum entry 6v6f
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protein ligands metals Protein-protein interface(s) links
Oncoprotein PDB id
6v6f

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
110 a.a.
301 a.a.
168 a.a.
Ligands
FMT ×4
GNP
Metals
_ZN
_MG
Waters ×25
PDB id:
6v6f
Name: Oncoprotein
Title: Crystal structure of q61l kras(gmppnp)-nf1(grd)-spred1(evh1) complex
Structure: Sprouty-related, evh1 domain-containing protein 1. Chain: a. Synonym: hspred1. Engineered: yes. Neurofibromin. Chain: b. Synonym: neurofibromatosis-related protein nf-1. Engineered: yes. Gtpase kras.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: spred1. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Gene: nf1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.54Å     R-factor:   0.220     R-free:   0.265
Authors: W.Yan,D.K.Simanshu
Date:
05-Dec-19     Release date:   15-Jul-20    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Q7Z699  (SPRE1_HUMAN) -  Sprouty-related, EVH1 domain-containing protein 1 from Homo sapiens
Seq:
Struc: 		444 a.a.
110 a.a.
Protein chain
P21359  (NF1_HUMAN) -  Neurofibromin from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		2839 a.a.
301 a.a.
Protein chain
P01116  (RASK_HUMAN) -  GTPase KRas from Homo sapiens
Seq:
Struc: 		189 a.a.
168 a.a.*
Key:    Secondary structure
* PDB and UniProt seqs differ at 7 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chain C: E.C.3.6.5.2  - small monomeric GTPase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: GTP + H2O = GDP + phosphate + H+
GTP
 + H2O
 =
GDP
Bound ligand (Het Group name = GNP)
matches with 81.82% similarity 		+ phosphate
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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