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PDBsum entry 6pdp
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Transferase/transferase inhibitor
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PDB id
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6pdp
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PDB id:
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| Name: |
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Transferase/transferase inhibitor
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Title:
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Human pim1 bound to benzothiophene inhibitor 379
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Structure:
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Serine/threonine-protein kinase pim-1. Chain: a. Engineered: yes. Peptide. Chain: b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: pim1. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Resolution:
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2.50Å
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R-factor:
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0.195
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R-free:
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0.230
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Authors:
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P.H.C.Godoi,D.Sriranganadane,A.S.Santiago,A.M.Fala,P.Z.Ramos, A.Mascarello,N.Segretti,H.Azevedo,C.R.W.Guimaraes,P.Arruda, J.M.Elkins,R.M.Counago,Structural Genomics Consortium (Sgc)
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Key ref:
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P.H.C.Godoi
et al.
Human pim1.
To be published,
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Date:
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19-Jun-19
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Release date:
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24-Jul-19
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PROCHECK
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Headers
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References
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P11309
(PIM1_HUMAN) -
Serine/threonine-protein kinase pim-1 from Homo sapiens
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Seq:
Struc:
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313 a.a.
268 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
