PDBsum entry 6m8h

Signaling protein

PDB id: 6m8h

Contents

Protein chain

315 a.a.

Ligands

GSP

Metals

_MG

Waters ×211

PDB id:

6m8h

Name:

Signaling protein

Title:

Crystal structure of the r208q mutant of g(i) subunit alpha-1

Structure:

Guanine nucleotide-binding protein g(i) subunit alpha-1. Chain: a. Synonym: adenylate cyclase-inhibiting g alpha protein. Engineered: yes. Mutation: yes

Source:

Rattus norvegicus. Rat. Organism_taxid: 10116. Gene: gnai1, gnai-1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.07Å R-factor: 0.168 R-free: 0.197

Authors:

R.Mascarenhas,J.Goossens,B.Leverson,S.Kothawala,M.Ballicora,K.Olsen, D.De Freitas,D.Liu

Key ref:

J.L.Goossens et al. Functional consequences of oncogenic mutations in the ii region of galphai1 and galphas proteins. To be published, .

Date:

21-Aug-18 Release date: 21-Aug-19

Protein chain

P10824  (GNAI1_RAT) -  Guanine nucleotide-binding protein G(i) subunit alpha-1 from Rattus norvegicus

Seq: 354 a.a.

Struc: 315 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.?