PDBsum entry 6csc

Oxo-acid-lyase

PDB id: 6csc

Contents

Protein chains

437 a.a. *

Ligands

COF ×2

CIT ×2

Waters ×146

* Residue conservation analysis

PDB id:

6csc

Name:

Oxo-acid-lyase

Title:

Chicken citrate synthase complex with trifluoroacetonyl-coa and citrate

Structure:

Citrate synthase. Chain: a, b. Ec: 4.1.3.7

Source:

Gallus gallus. Chicken. Organism_taxid: 9031. Organ: heart. Tissue: muscle. Organelle: mitochondria. Cellular_location: inner matrix

Biol. unit:

Homo-Dimer (from PDB file)

Resolution:

2.25Å R-factor: 0.158

Authors:

K.C.Usher,S.J.Remington

Key ref:

K.C.Usher et al. Trifluoroacetonyl coenzyme a, An inhibitor of citrate synthase, Binds in a combination of productive and nonproductive modes. To be published, .

Date:

19-Jun-97 Release date: 24-Dec-97

Protein chains

P23007  (CISY_CHICK) -  Citrate synthase, mitochondrial from Gallus gallus

Seq: 433 a.a.

Struc: 437 a.a.*

* PDB and UniProt seqs differ at 31 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.3.1 - citrate (Si)-synthase.
• Pathway: Citric acid cycle
• Reaction: oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H⁺

oxaloacetate (Bound ligand (Het Group name = COF) matches with 89.29% similarity) + acetyl-CoA + H2O = citrate (Bound ligand (Het Group name = CIT) corresponds exactly) + CoA + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site