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PDBsum entry 6b8h
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protein ligands metals Protein-protein interface(s) links
Membrane protein PDB id
6b8h

 

 

 

 

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Contents
Protein chains
(+ 14 more) 75 a.a.
48 a.a.
249 a.a.
200 a.a.
157 a.a.
49 a.a.
84 a.a.
106 a.a.
59 a.a.
24 a.a.
(+ 0 more) 501 a.a.
(+ 0 more) 470 a.a.
265 a.a.
119 a.a.
48 a.a.
161 a.a.
21 a.a.
Ligands
ANP ×10
Metals
_MG ×10
PDB id:
6b8h
Name: Membrane protein
Title: Mosaic model of yeast mitochondrial atp synthase monomer
Structure: Atp synthase subunit 9, mitochondrial. Chain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 0, l, m, n, p, q, r, s, t, u, j. Synonym: lipid-binding protein,oligomycin resistance protein 1. Atp synthase protein 8. Chain: a, v. Synonym: a6l,atp-associated protein 1,f-atpase subunit 8. Atp synthase subunit a. Chain: a, p. Synonym: f-atpase protein 6.
Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Saccharomyces cerevisiae. Organism_taxid: 4932. Strain: atcc 204508 / s288c
Authors: H.Guo,S.A.Bueler,J.L.Rubinstein
Key ref: H.Guo et al. (2017). Atomic model for the dimeric FOregion of mitochondrial ATP synthase. Science, 358, 936-940. PubMed id: 29074581 DOI: 10.1126/science.aao4815
Date:
07-Oct-17     Release date:   17-Jan-18    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
P61829  (ATP9_YEAST) -  ATP synthase subunit 9, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		76 a.a.
75 a.a.
Protein chains
Pfam   ArchSchema ?
P00856  (ATP8_YEAST) -  ATP synthase protein 8 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		48 a.a.
48 a.a.
Protein chains
Pfam   ArchSchema ?
P00854  (ATP6_YEAST) -  ATP synthase subunit a from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		259 a.a.
249 a.a.
Protein chains
Pfam   ArchSchema ?
P05626  (ATPF_YEAST) -  ATP synthase subunit 4, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		244 a.a.
200 a.a.
Protein chains
Pfam   ArchSchema ?
P30902  (ATP7_YEAST) -  ATP synthase subunit d, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		174 a.a.
157 a.a.
Protein chains
No UniProt id for this chain
Struc: 49 a.a.
Protein chains
Pfam   ArchSchema ?
Q06405  (ATPK_YEAST) -  ATP synthase subunit f, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		101 a.a.
84 a.a.
Protein chains
No UniProt id for this chain
Struc: 106 a.a.
Protein chains
Pfam   ArchSchema ?
P81450  (ATP18_YEAST) -  ATP synthase subunit J, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		59 a.a.
59 a.a.
Protein chains
Pfam   ArchSchema ?
P81451  (ATP19_YEAST) -  ATP synthase subunit K, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		68 a.a.
24 a.a.
Protein chains
Pfam   ArchSchema ?
P07251  (ATPA_YEAST) -  ATP synthase subunit alpha, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		 
Seq:
Struc: 		545 a.a.
501 a.a.
Protein chains
Pfam   ArchSchema ?
P00830  (ATPB_YEAST) -  ATP synthase subunit beta, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		511 a.a.
470 a.a.
Protein chains
Pfam   ArchSchema ?
P38077  (ATPG_YEAST) -  ATP synthase subunit gamma, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		311 a.a.
265 a.a.
Protein chains
Pfam   ArchSchema ?
Q12165  (ATPD_YEAST) -  ATP synthase subunit delta, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		160 a.a.
119 a.a.
Protein chains
Pfam   ArchSchema ?
E9P9X4  (E9P9X4_YEASX) -  ATP synthase catalytic sector F1 epsilon subunit from Saccharomyces cerevisiae
Seq:
Struc: 		62 a.a.
48 a.a.
Protein chains
Pfam   ArchSchema ?
P09457  (ATPO_YEAST) -  ATP synthase subunit 5, mitochondrial from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		212 a.a.
161 a.a.
Protein chains
No UniProt id for this chain
Struc: 21 a.a.
Key:    PfamA domain  Secondary structure

 Enzyme reactions 
   Enzyme class: Chains D, E, F, Y, Z, c: E.C.7.1.2.2  - H(+)-transporting two-sector ATPase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + H2O + 4 H+(in) = ADP + phosphate + 5 H+(out)
ATP
 + H2O
 + 4 × H(+)(in)
 =
ADP
Bound ligand (Het Group name = ANP)
matches with 81.25% similarity 		+ phosphate
 + 5 × H(+)(out)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
DOI no: 10.1126/science.aao4815 Science 358:936-940 (2017)
PubMed id: 29074581  
 
 
Atomic model for the dimeric FOregion of mitochondrial ATP synthase.
H.Guo, S.A.Bueler, J.L.Rubinstein.
 
  ABSTRACT  
 
Mitochondrial adenosine triphosphate (ATP) synthase produces the majority of ATP in eukaryotic cells, and its dimerization is necessary to create the inner membrane folds, or cristae, characteristic of mitochondria. Proton translocation through the membrane-embedded FOregion turns the rotor that drives ATP synthesis in the soluble F1region. Although crystal structures of the F1region have illustrated how this rotation leads to ATP synthesis, understanding how proton translocation produces the rotation has been impeded by the lack of an experimental atomic model for the FOregion. Using cryo-electron microscopy, we determined the structure of the dimeric FOcomplex fromSaccharomyces cerevisiaeat a resolution of 3.6 angstroms. The structure clarifies how the protons travel through the complex, how the complex dimerizes, and how the dimers bend the membrane to produce cristae.
 

 

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