PDBsum entry 5udc

Viral protein/immune system

PDB id: 5udc

Contents

Protein chains

217 a.a.

211 a.a.

449 a.a.

Ligands

NAG-NAG-BMA-MAN-MAN-MAN-MAN-MAN-MAN-MAN-MAN

Metals

_CL ×2

PDB id:

5udc

Name:

Viral protein/immune system

Title:

Crystal structure of rsv f a2 bound to medi8897

Structure:

Medi8897 fab heavy chain. Chain: h, b, e. Engineered: yes. Medi8897 fab light chain. Chain: l, c, g. Engineered: yes. Fusion glycoprotein f0. Chain: f, a, d. Synonym: protein f.

Source:

Homo sapiens. Organism_taxid: 9606. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: 293f. Human respiratory syncytial virus a (strain a2). Organism_taxid: 11259. Strain: a2.

Resolution:

3.45Å R-factor: 0.178 R-free: 0.232

Authors:

J.S.Mclellan

Key ref:

Q.Zhu et al. (2017). A highly potent extended half-Life antibody as a pote rsv vaccine surrogate for all infants.. Sci transl med, 9, . PubMed id: 28469033

Date:

26-Dec-16 Release date: 17-May-17

Protein chains

No UniProt id for this chain

Struc: 217 a.a.

Protein chains

No UniProt id for this chain

Struc: 211 a.a.

Protein chains

P03420  (FUS_HRSVA) -  Fusion glycoprotein F0 from Human respiratory syncytial virus A (strain A2)

Seq: 574 a.a.

Struc: 449 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)