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PDBsum entry 5thr
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protein ligands Protein-protein interface(s) links
Viral protein PDB id
5thr

 

 

 

 

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Contents
Protein chains
124 a.a.
364 a.a.
98 a.a.
107 a.a.
127 a.a.
131 a.a.
107 a.a.
Ligands
NAG-NAG-BMA-MAN ×3
NAG-NAG-BMA-MAN-
MAN ×6
PDB id:
5thr
Name: Viral protein
Title: Cryo-em structure of a bg505 env-scd4-17b-8anc195 complex
Structure: Bg505 sosip gp41. Chain: a, b, c. Fragment: unp residues 509-661. Engineered: yes. Bg505 sosip gp120. Chain: d, e, f. Fragment: unp residue 30-505. Engineered: yes. T-cell surface glycoprotein cd4.
Source: Human immunodeficiency virus 1. Organism_taxid: 11676. Gene: env. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293 6e. Homo sapiens. Human. Organism_taxid: 9606.
Authors: H.Wang,P.J.Bjorkman
Key ref: H.Wang et al. (2016). Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop. Proc Natl Acad Sci U S A, 113, E7151. PubMed id: 27799557 DOI: 10.1073/pnas.1615939113
Date:
30-Sep-16     Release date:   16-Nov-16    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q2N0S6  (Q2N0S6_HV1) -  Envelope glycoprotein gp160 from Human immunodeficiency virus type 1
Seq:
Struc: 		 
Seq:
Struc: 		860 a.a.
124 a.a.*
Protein chains
Pfam   ArchSchema ?
Q2N0S6  (Q2N0S6_HV1) -  Envelope glycoprotein gp160 from Human immunodeficiency virus type 1
Seq:
Struc: 		 
Seq:
Struc: 		860 a.a.
364 a.a.*
Protein chains
Pfam   ArchSchema ?
P01730  (CD4_HUMAN) -  T-cell surface glycoprotein CD4 from Homo sapiens
Seq:
Struc: 		458 a.a.
98 a.a.
Protein chains
No UniProt id for this chain
Struc: 107 a.a.
Protein chains
No UniProt id for this chain
Struc: 127 a.a.
Protein chains
No UniProt id for this chain
Struc: 131 a.a.
Protein chains
No UniProt id for this chain
Struc: 107 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 3 residue positions (black crosses)

 

 
DOI no: 10.1073/pnas.1615939113 Proc Natl Acad Sci U S A 113:E7151 (2016)
PubMed id: 27799557  
 
 
Cryo-EM structure of a CD4-bound open HIV-1 envelope trimer reveals structural rearrangements of the gp120 V1V2 loop.
H.Wang, A.A.Cohen, R.P.Galimidi, H.B.Gristick, G.J.Jensen, P.J.Bjorkman.
 
  ABSTRACT  
 
No abstract given.

 

 

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