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PDBsum entry 5svh
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protein ligands metals Protein-protein interface(s) links
Transcription PDB id
5svh

 

 

 

 

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Contents
Protein chains
85 a.a.
42 a.a.
Ligands
GOL ×2
Metals
_CL ×7
Waters ×100
PDB id:
5svh
Name: Transcription
Title: Crystal structure of the kix domain of cbp in complex with a mll/c-myb chimera
Structure: Creb-binding protein. Chain: a. Fragment: unp residues 587-673. Engineered: yes. Mll/c-myb chimera. Chain: b. Fragment: unp q03164 residues 2839-2869 linked to unp p01103 residues 291-315,unp q03164 residues 2839-2869 linked to unp p01103 residues 291-315.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: crebbp, cbp. Expressed in: escherichia coli. Expression_system_taxid: 562. Homo sapiens, gallus gallus. Human, chicken. Organism_taxid: 9606, 9031.
Resolution:
2.05Å     R-factor:   0.208     R-free:   0.242
Authors: D.N.Langelaan,S.P.Smith,J.A.Allingham
Key ref: D.N.Langelaan and s.p.smith Design of a nanomolar affinity ligand to the kix doma cbp. To be published, .
Date:
06-Aug-16     Release date:   09-May-18    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q92793  (CBP_HUMAN) -  CREB-binding protein from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		2442 a.a.
85 a.a.
Protein chain
Pfam   ArchSchema ?
P01103  (MYB_CHICK) -  Transcriptional activator Myb from Gallus gallus
Seq:
Struc: 		 
Seq:
Struc: 		641 a.a.
42 a.a.*
Protein chain
Pfam   ArchSchema ?
Q03164  (KMT2A_HUMAN) -  Histone-lysine N-methyltransferase 2A from Homo sapiens
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		 
Seq:
Struc: 		3969 a.a.
42 a.a.*
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 37 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 1: Chain A: E.C.2.3.1.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 2: Chain A: E.C.2.3.1.48  - histone acetyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-lysyl-[protein] + acetyl-CoA = N6-acetyl-L-lysyl-[protein] + CoA + H+
L-lysyl-[protein]
 + acetyl-CoA
 = N(6)-acetyl-L-lysyl-[protein]
 + CoA
 + H(+)
   Enzyme class 3: Chain B: E.C.2.1.1.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
   Enzyme class 4: Chain B: E.C.2.1.1.364  - [histone H3]-lysine(4) N-methyltransferase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: L-lysyl4-[histone H3] + S-adenosyl-L-methionine = N6-methyl-L- lysyl4-[histone H3] + S-adenosyl-L-homocysteine + H+
L-lysyl(4)-[histone H3]
 + S-adenosyl-L-methionine
 = N(6)-methyl-L- lysyl(4)-[histone H3]
 + S-adenosyl-L-homocysteine
 + H(+)
   Enzyme class 5: Chain B: E.C.2.1.1.43  - Transferred entry: 2.1.1.354.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone]
S-adenosyl-L-methionine
 + L-lysine-[histone]
 = S-adenosyl-L-homocysteine
 + N(6)-methyl-L-lysine-[histone]
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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