PDBsum entry 5l6t

Lyase/inhibitor

PDB id: 5l6t

Contents

Protein chains

258 a.a.

Ligands

6H0 ×2

GOL ×4

QVS-QUK-QVE

QCL-QVS-QUK-QVE

QCL

Metals

_ZN ×15

Waters ×177

PDB id:

5l6t

Name:

Lyase/inhibitor

Title:

Crystal structure of human carbonic anhydrase ii in complex with a quinoline oligoamide foldamer

Structure:

Carbonic anhydrase 2. Chain: a, b. Synonym: carbonate dehydratase ii,carbonic anhydrasE C,cac,carbonic anhydrase ii,ca-ii. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ca2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

2.65Å R-factor: 0.223 R-free: 0.278

Authors:

M.Vallade,B.Langlois D'Estaintot,T.Granier,I.Huc

Key ref:

M.Vallade et al. Crystal structure of human carbonic anhydrase ii in c with a quinoline oligoamide foldamer. To be published, .

Date:

31-May-16 Release date: 21-Jun-17

Protein chains

P00918  (CAH2_HUMAN) -  Carbonic anhydrase 2 from Homo sapiens

Seq: 260 a.a.

Struc: 258 a.a.

Enzyme reactions

• Enzyme class 2: E.C.4.2.1.1 - carbonic anhydrase.
• Reaction: hydrogencarbonate + H⁺ = CO2 + H2O
• Cofactor: Zn(2+)
• Enzyme class 3: E.C.4.2.1.69 - cyanamide hydratase.
• Reaction: urea = cyanamide + H2O

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site