PDBsum entry 5l2s

Transferase/transferase inhibitor

PDB id: 5l2s

Contents

Protein chain

263 a.a.

Ligands

6ZV

Waters ×21

PDB id:

5l2s

Name:

Transferase/transferase inhibitor

Title:

The x-ray co-crystal structure of human cdk6 and abemaciclib.

Structure:

Cyclin-dependent kinase 6. Chain: a. Fragment: unp residues 1-301. Synonym: cell division protein kinase 6,serine/threonine-protein kinase plstire. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.27Å R-factor: 0.209 R-free: 0.249

Authors:

P.Chen,R.A.Ferre,W.Deihl,X.Yu,Y.-A.He

Key ref:

P.Chen et al. (2016). Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance. Mol Cancer Ther, 15, 2273-2281. PubMed id: 27496135 DOI: 10.1158/1535-7163.MCT-16-0300

Date:

02-Aug-16 Release date: 24-Aug-16

Protein chain

Q00534  (CDK6_HUMAN) -  Cyclin-dependent kinase 6 from Homo sapiens

Seq: 326 a.a.

Struc: 263 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.22 - cyclin-dependent kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1158/1535-7163.MCT-16-0300

Mol Cancer Ther 15:2273-2281 (2016)

PubMed id: 27496135

Spectrum and Degree of CDK Drug Interactions Predicts Clinical Performance.

P.Chen, N.V.Lee, W.Hu, M.Xu, R.A.Ferre, H.Lam, S.Bergqvist, J.Solowiej, W.Diehl, Y.A.He, X.Yu, A.Nagata, T.VanArsdale, B.W.Murray.

ABSTRACT

No abstract given.