PDBsum entry 5hqe

Oxidoreductase/inhibitor

PDB id: 5hqe

Contents

Protein chain

365 a.a.

Ligands

64B

FMN

ORO

SO4 ×3

ACT ×3

Waters ×162

PDB id:

5hqe

Name:

Oxidoreductase/inhibitor

Title:

Crystal structure of human dihydroorotate dehydrogenase (dhodh) with compound 18t

Structure:

Dihydroorotate dehydrogenase (quinone), mitochondrial. Chain: a. Fragment: unp residues 29-395. Synonym: dhodehase,dihydroorotate oxidase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: dhodh. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Resolution:

1.62Å R-factor: 0.161 R-free: 0.182

Authors:

J.Huang,D.Wu,Q.Lu

Key ref:

J.Huang et al. Crystal structure of human dihydroorotate dehydrogena (dhodh) with 18t at 1.62 a resolution. To be published, .

Date:

21-Jan-16 Release date: 27-Jul-16

Protein chain

Q02127  (PYRD_HUMAN) -  Dihydroorotate dehydrogenase (quinone), mitochondrial from Homo sapiens

Seq: 395 a.a.

Struc: 365 a.a.

Enzyme reactions

• Enzyme class: E.C.1.3.5.2 - dihydroorotate dehydrogenase (quinone).
• Reaction: (S)-dihydroorotate + a quinone = orotate + a quinol

(S)-dihydroorotate (Bound ligand (Het Group name = ORO) corresponds exactly) + quinone = orotate + quinol

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site