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PDBsum entry 5e3h
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Hydrolase/RNA
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PDB id
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5e3h
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PDB id:
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Hydrolase/RNA
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Title:
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Structural basis for RNA recognition and activation of rig-i
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Structure:
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Probable atp-dependent RNA helicase ddx58. Chain: a. Fragment: unp residues 232-925. Synonym: dead box protein 58,rig-i-like receptor 1,rlr-1,retinoic acid-inducible gene 1 protein,rig-1,retinoic acid-inducible gene i protein,rig-i. Engineered: yes. RNA (5'-r( Cp Gp Ap Cp Gp Cp Up Ap Gp Cp Gp U)-3'). Chain: b, c.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ddx58. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630
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Resolution:
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2.70Å
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R-factor:
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0.236
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R-free:
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0.268
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Authors:
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F.Jiang,M.T.Miller,J.Marcotrigiano
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Key ref:
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F.Jiang
et al.
(2011).
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
Nature,
479,
423-427.
PubMed id:
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Date:
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02-Oct-15
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Release date:
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18-Nov-15
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Supersedes:
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PROCHECK
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Headers
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References
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O95786
(DDX58_HUMAN) -
Antiviral innate immune response receptor RIG-I from Homo sapiens
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Seq:
Struc:
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925 a.a.
642 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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C-G-A-C-G-C-U-A-G-C-G-U
12 bases
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A-C-G-C-U-A-G-C-G-U-C-G
12 bases
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Enzyme class:
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E.C.3.6.4.13
- Rna helicase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
Bound ligand (Het Group name = )
corresponds exactly
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Nature
479:423-427
(2011)
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PubMed id:
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Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
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F.Jiang,
A.Ramanathan,
M.T.Miller,
G.Q.Tang,
M.Gale,
S.S.Patel,
J.Marcotrigiano.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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Y.M.Abbas,
A.Pichlmair,
M.W.Górna,
G.Superti-Furga,
and
B.Nagar
(2013).
Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.
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Nature,
494,
60-64.
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PDB codes:
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A.L.Mallam,
M.Del Campo,
B.Gilman,
D.J.Sidote,
and
A.M.Lambowitz
(2012).
Structural basis for RNA-duplex recognition and unwinding by the DEAD-box helicase Mss116p.
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Nature,
490,
121-125.
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PDB codes:
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X.Jiang,
and
Z.J.Chen
(2012).
The role of ubiquitylation in immune defence and pathogen evasion.
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Nat Rev Immunol,
12,
35-48.
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
