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PDBsum entry 5c6h
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Apoptosis/apoptosis regulator
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PDB id
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5c6h
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Contents |
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(+ 6 more)
155 a.a.
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25 a.a.
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(+ 1 more)
26 a.a.
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24 a.a.
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23 a.a.
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PDB id:
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| Name: |
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Apoptosis/apoptosis regulator
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Title:
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Mcl-1 complexed with mule
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Structure:
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Induced myeloid leukemia cell differentiation protein mcl- 1. Chain: a, c, e, g, i, k, m, o, q, s, u, w. Fragment: unp residues 171-327. Synonym: bcl-2-like protein 3,bcl2-l-3,bcl-2-related protein eat/mcl1,mcl1/eat. Engineered: yes. Other_details: mcl-1, residues 171-327. Mule bh3 peptide from e3 ubiquitin-protein ligase huwe1.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: mcl1, bcl2l3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
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Resolution:
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2.05Å
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R-factor:
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0.297
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R-free:
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0.346
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Authors:
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T.Song,Z.Wang,F.Ji,G.Chai,Y.Liu,X.Li,Z.Li,Y.Fan,Z.Zhang
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Key ref:
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T.Song
et al.
Structure of mcl-1 complexed with mule at 2.05 angstr resolution.
To be published,
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Date:
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23-Jun-15
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Release date:
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03-Aug-16
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PROCHECK
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Headers
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References
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Q07820
(MCL1_HUMAN) -
Induced myeloid leukemia cell differentiation protein Mcl-1 from Homo sapiens
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Seq:
Struc:
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350 a.a.
155 a.a.
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Q7Z6Z7
(HUWE1_HUMAN) -
E3 ubiquitin-protein ligase HUWE1 from Homo sapiens
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Seq:
Struc:
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4374 a.a.
25 a.a.
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Q7Z6Z7
(HUWE1_HUMAN) -
E3 ubiquitin-protein ligase HUWE1 from Homo sapiens
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Seq:
Struc:
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4374 a.a.
26 a.a.
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Enzyme class:
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Chains B, D, F, H, J, L, N, P, R, T, V, X:
E.C.2.3.2.26
- HECT-type E3 ubiquitin transferase.
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Reaction:
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S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6- ubiquitinyl-[acceptor protein]-L-lysine
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Links
